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Research has identified potential interactions with NMDA receptor modulation and MAPK signalling pathways, with data suggesting structural homology to glucocorticoid-induced leucine zipper (GILZ) a protein involved in anti-inflammatory and immune-regulatory signalling via the ERK pathway

In addition, according to the astrocyte-neuron lactate shuttle hypothesis, glutamate stimulated metabolism of glucose in astrocytes produces lactate which can be transferred to neurons to be utilized as fuel (Pellerin and Magistretti, 1994)

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